![]() ![]() Grainger, R., Cornella, J., Blakemore, D. Huang, L., Biafora, A., Zhang, G., Bragoni, V. Discover unique things to do, places to eat, and sights to see in the best destinations around the world with Bring Me HuffPost News, Politics, Culture, Life, Entertainment, and more. Recently, tremendous progress in engineering directing groups has also made the meta position accessible 3. As a direct consequence of this, a plethora of directing groups have been successfully exploited for ortho C–H functionalization of arenes 2. ![]() Currently, one of the most powerful tools to control the regioselectivity of a C–H functionalization reaction is to use a directing group: a substituent or functional group on the ring that is able to coordinate to the transition metal catalyst and bring it into the proximity of a specific C–H bond, thus lowering its activation barrier. If we consider the simple case of a monosubstituted benzene ring, three different C–H bonds can potentially be activated ( ortho, meta and para). However, in view of the ubiquitous nature of C–H bonds in organic molecules, controlling the site selectivity - reacting a specific C–H bond that is among several others - is a challenging task. In particular, C–H activation 1 has been shown to be an important approach for transforming normally inert C–H bonds into reactive intermediates that are then engaged in elegant chemical transformations. ![]() Researchers in the field of metal-catalysed C–H functionalization have developed a number of efficient cross-coupling technologies. ![]()
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